Seems like something that would happen if you went too far away from her. I've had the same happen with Skeletron Prime, except they just descend to hell and never come back.
I don't know if you need to be in the Jungle to fight her, but if you do, that might also be the cause.
Pretty sure you can fight QB outside the jungle/beehive, maybe I might have gone too far from her? I honestly don't know, in my screen she wasn't that far she just straight up ascended to the heavens and never returned. lol
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I don't know if you need to be in the Jungle to fight her, but if you do, that might also be the cause.