as a person doing the fully corrupted challenge, i got a tip for those who want to try the challenge..
Make the ebonwood/shadewood sword as soon as possible (it should do enough damage to make clear of some of the enemies)
a 2nd tip is if you die alot and you got a graveyard, mine the blocks underneath the gravestone (its faster than mining the grave directly)
(Since most of the sci-fi stuff is mage and especially ranger items.)