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Considering the fact that you have to pretty much endure every single hit, yes.

Endgame Melee can use intelligent building to make it so hits are few and far between, thanks to the peculiarities of several melee weapons which are often ignored as "useless" or "too situational."

For example, the North Pole can shoot its crystals through walls. Non-clipper monsters can be mowed down forever.

Admittedly, it's a bit more challenging than "stand there with infinite ammo and mow things down while not caring about your health" or "stand there with near-infinite ammo and move now and then to make sure you don't die."

Nope

Mage is easy, if you use godmode armor. You can make it a challenge, by not using godmode armor. And if you're too used to shooting things from afar, then of course going for a closer approach will be a challenge.

Also, what's cooler and neater than a spear that shoots icicles?