Can somebody give me some tips for defeating the mech bosses

A few quick tips:
  • Get a pair of wings for mobility.
  • Make sure you have adamantite / titanium armour (or equivalent or better) - Molten Armour won't let you survive long
  • Build a proper arena. Especially focus on platforms well above ground level. Skeletron Prime's bombs will fall through platforms. Destroyer can't dig through platforms, so you'll catch it on its apex as it falls back to the ground.
  • Use potions.
  • Take in a summon or two. All classes can have one summon active (two with the Bewitching Table).
 
Use a Daedalus Stormbow with Holy Arrows for the Destroyer and Twins. Switch to Ichor arrows and then spam Onyx Blaster with Crystal bullets for Prime. As for armor, your best choices are Titanium and Palladium, with the Squire's Great Helm becoming available after one mech (you'll have to go out of your way to get it, but the helmet alone provides about as much regen as a full set of crimson armor.)
 
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