1 - Panic button. a weapon that requires 0 aiming, and either has ridiculous DPS, or ridiculous knockback. for instance, i am using that new crimson tigerclaw weapon. i have it on Weak modifiers, which reduce its knockback even more. having 70 damage with a use time of 4... it shreds everything, even bosses. will replace with slap-hand if possible.
2 - flying knife. most used weapon, it fits exploration and combat, goes around any obstacle, goes through some walls, penetrates like no tomorrow. overall super versatile.
3 - ranged DPS: megashark.
4 - Ranged groupslayer: dart rifle + crystal darts kills an average of 3 mobs a shot with orichalchum ranger set. plus ricochets keep the petals coming for even MORE damage.
5, 6, 7 - Area Denial: a deadly mix of the Staff of the Frost Hydra, the Nymbus Rod, and that corruption fire wall thingy. i am untouchable in AFK with just this.
8 - Ice Rod: for constricting dangerous enemies like special mimics, making temporary bridges, mining in peace, helping to traverse difficult terrain with hooks, and attacking impunely. i have a Myhtical one :O that thing is awesome
9 - Summons: i love the twins. works for everything.
10 - Mirror Magic, Mirror Mine, Take me Home and Let me Whine.