I'm having two problems in my latest playthrough that I'm pretty sure are caused by one of these mods.
1. Melee weapons hit enemies multiple times in their arc, once per frame. Problem is not bad in singleplayer, but disastrous in multiplayer (enemy health rubberbands, enemies teleporting, etc) to the point where melee weapons are unusable in multiplayer.
2. Minions and any item that targets enemies (i don't know how else to put it, but two items that are affected are the Laser Drill and the Taser from Calamity) disappear the moment they touch an enemy, making the only minions that are useful are ones that are equipped as an accessory.