Xylia
Terrarian
Technically you don’t even need to kill the evil boss. You can kill less than half of boc’s creepers (including in master mode where the droprates are nerfed, where you need to only kill 8/20 of them) and then on average you’ll have enough tissue samples to craft an evil pickaxe without even finishing the fight, which means you can underprepare for the boss and still get the reward even if you fail, which is silly.
Well, yeah, I meant fight the boss, lol. But that would take a few summons as the final kill of the boss gives a bunch of the item + ore IIRC.
Either way... getting a PB early isn't that hard.