Calamity changes too much of the game to make support conceivable, sadly.
Understandable but it is a shame.
It would be nice to have a tier (or two) that would be scaled to be competitive with endgame stuff from some of the big mods such as Calamity. Hopefully we'll see some addons to this mod that bridge connections a bit.
It would also be really cool to see integration with some of the class mods (the ones that add defined character class roles). I'm pretty impressed with what you've come up with here and there is definite potential for this mod to be big.