I have a slight update for that, it only works when not done from the hot bar. If a mana star is selected in your inventory when you close your inventory they get deleted from the game, with sometimes showing the effect of you using it. This is also true for heart crystals. I lost 4 mana stars and 2 heart crystals trying to figure this out.
@Deanzor can you see if this is recreatible on any dev N3DS's.
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The spawn rates are a bit higher then normal. I think this could be a side effect of making everything a bit toughened.
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@Deanzor, is there any chance of NPC's defending themselves
It's kinda annoying during events having tons of NPCs slaughtered.