@TiberiumFusion's biggest problem with updating is knowing exactly what is broken. Just saying it doesn't work is stress inducing and not very helpful.
There are now multiple mentions of crashing in this thread but not a single mention of a specific Tweak that causes a crash.
Please take the time to enable the mods one at a time and identify exactly which are broken if you want fixes. If you want to speed things up disable about half of your tweaks at a time till it works, then start adding back the remaining mods half at a time. You can copy your tweak list before going through this process so you don't lose your settings.
If you have identified a specific tweak that is broken and you can't live without, you can coordinate with other TT2 users here to make a plugin substitute to hold you over.