Skeletron/Skeletron Prime share that trait too. Unless you save and quit, which I believe doing so against WoF doesn't work to your favour.
I'm still pondering how to kill Skeletron Prime with 102k health. Oh, and double defence too, I forgot about that. That will make using the Megashark with Crystal bullets real hard against it.
Skeletron/Prime become basically a Dungeon Guardian when the sun rises. Just have your fancy tricks ready, and they can still be killed - in ten or twenty minutes more.
I was once fighting "Dungeon Guardian Prime" with my gf for fun, took too much to beat it, and the Twins decided to auto-spawn and join the party. So many deaths.
By the way, to add a bit of context: I'm doing a play-through where every mob had 5x the health and 2x the defence. With @W1K 's mod, credit's given where credit's due.
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On a small, I would have needed more aggressive tactics such as Molten Fury+Holy Arrows or Demon Scythe.