I would probably just allow world transfer, but it's interesting to see how much is possible in a single world.
That said, you're kinda out of luck with purification powder/solution in a GetFixedBoi seed though.
Nah, you can do and play with it how you like.
Even if my playthroughs are usually with one character in one world, it's never a strict restriction.
In fact, I also use my main world as a collectors hub
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