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I use vampire knives against him as well.

I'm on mobile.

Try a possessed hatchet

I do have that, would I use any potions or buffs?

yeah, potions and buffs are really influential in battles

Not really a fan of having to scrounge up the materials to craft them so I barely ever use them. I hardly have any ichor because my main world is corruption to make enough ichor flasks to have a bunch of battles with him.

I did make a ichor spell to have a more permanent ichor item, was this a mistake? The effect seems to wear off after a few seconds and I don't want to have to switch back and forth between my melee weapon and the ichor spell all the time, or farm ichor for flasks.

I defeated duke fishron a second time and got the stupid razorblade typhoon spell (AGAIN) I'm done with this. It takes me forever for a single truffle worm to spawn, and most of the time I get killed by duke fishron and the only two times I didnt guy I got a weapon I can't even use for my character.

I now have gotten four razorblade tycoons...

Presuming that you play on mobile, the UI/screen is really cluttered and small, making it difficult to predict his movements when he is constantly out of your sight. Additionally, that makes it easier for him to hit him vs you hitting him, and thus vampire knives are not going to cut it as they heal so little life compared to how much life he takes from you per hit.

I've beat him all four times with vampire knives. My problem now is the bad luck with drops... Haven't played after the fourth time so I haven't tried my luck in fighting him again.