Sargon
Terrarian
I imagine that a lot of people could play the game a lot and never get one-shot by a random Medusa, being killed by one like that is heavily dependent on the structure of the caves around you. Unfortunately though, I'm not that lucky, and when it does happen it's one of the most infuriating things I've experienced in Terraria. As for the desert spirits, I think that might be because a lot of people might have ignored the underground desert in hardmode, so they never even saw them like me.
Truly, RNGesus plays a part in this. Perhaps you should hate him more than your beautiful Medusa.
I don't see why people even take deaths that seriously, unless you play mediumcore/hardcore.
It's not that big a deal.
For instance, I was mining and I stepped on an explosive trap. I laughed.
I activate detonators because it's fun.
I honestly don't care about death.
Well... You should never take games too seriously.