Straying too far from the
Ocean area (more than 400 tiles from the (unreachable) lateral edge of the world) during the fight causes Duke Fishron to "enrage" (similar to
Plantera's "enraged" behavior outside the
Underground Jungle), causing him to lunge at the player continuously, deal double damage, gain double defense, as well as becoming faster and firing more frequent and faster Cthulhunados.
- Altitude also matters: If the player is below surface level or within 50 tiles from the top of the map (due to part of the map being unreachable, this distance is around 13 tiles in-game), Duke Fishron will enrage.