Elienai, if you want to block some enemies from spawning you could use Cheat Sheet or Hamstars Nihilism Mod. Nihilism lets you block certain enemies
and items so that they don't spawn, its a great mod but needs to be customized per config to be of use for you, Cheat Sheet is much easier to use, which is
why i might recommend you to check this mod out. You dont need to use its Cheat Features like Item Browser, etc. (you can even disable them), but you can
easily use the NPC Browser to disable creatures you dont like. Just search for the ones you want to get rid off and right-click on them to disable them.
Personally, I don't use it to cheat at all, but its great for building and stuff, too. So no need to restart your playthrough, even though its not a good idea
to combine Overhaul with other mods, as its been said already. Hope that helps.
Oh, and Dan Yami : I don't post here regulary, and I never even posted here in this thread, but I've been using Sacred Tools / Shadows of Abaddon since a long time,
and I have to say, its by far the mod which advanced the most both in quality and size since its original release, and I played many. Keep up the good work!