Kola17_97
Spazmatism
My picks would be the Kobra pistols and the GAL-43 Sub-Machine guns from Saints Row 2. Most if not all of the missions throughout each of the gang story arcs involve lots of simultaneous running and shooting without time for aiming finely so having those is practically dominant strategy in most of the combat related situations. Plus having the ability to dual wield them and have infinite ammo if you complete the instances of the activities that you unlock those rewards in.
EDIT: You can unlock these pretty freaking early as well, before you even do the gang missions.
EDIT: You can unlock these pretty freaking early as well, before you even do the gang missions.