This is a thread about testing different weapons vs Skeletron Prime. I'm posting it now to get it up here, and plan on improving it (converting more times to seconds, adding color, etc.).
means that this weapon requires having defeated a mechanical boss previously.
Setup:
Buffs used: Pad thai, wrath potion, ironskin, regeneration, endurance, magic power potion, archery potion, flask of ichor, sharpened, bewitching table, clairvoyance
Not used: summon potion (I rarely use this in my own playthroughs)
Non-summoners used 2 sanguine bats each.
Top-10 pre-mech weapons (color indicates safety, with green safest, then yellow, then orange):
Melee:
Magic:
Summoner
(Abigail with obsidian armor is the last thing I tried, and I was dying a lot, and she was too slow to catch up, so she's not included).
Ranged:

Setup:
- Armor used: Adamantite (for every but summoner), spider armor, obsidian armor
- Accessories used: fairy wings, amphibian boots, ankh shield, and (all except for summoner) shield of cthulhu
- Melee accessories: berserker glove, warrior emblem, yo-yo bag replacing shield of cthulhu for yoyos
- Ranger accessories: molten quiver/putrid scent, ranger emblem
- Mage accessories: mana cloak, mage emblem
- Summoner accessories: pygmy necklace, berseker glove, summoner emblem
Buffs used: Pad thai, wrath potion, ironskin, regeneration, endurance, magic power potion, archery potion, flask of ichor, sharpened, bewitching table, clairvoyance
Not used: summon potion (I rarely use this in my own playthroughs)
Non-summoners used 2 sanguine bats each.
Top-10 pre-mech weapons (color indicates safety, with green safest, then yellow, then orange):
- 77 daedalus stormbow, ichor arrows
- 92 uzi, ichor bullets
- 95 sanguine bats, firecracker, spider armor
- 98 onyx blaster, ichor bullets, medium
- 99 orange zapinator
- 102 Daedalus stormbow, holy arrows
- 102 onyx blaster, crystal bullets
- 104 sanguine bats, firecracker, obsidian armor
- 112 dart pistol, ichor darts
- 115 magic dagger
- 67
super star shooter
- 71
megashark, ichor bullets
- 77
pulse bow, ichor arrows
- 82
megashark, crystal bullets
- 83
Phantom phoenix, ichor arrows
- 85
Flamethrower
- 85
unholy trident
- 89
phantom pheonix, holy arrows
- 91
tome of infinite wisdom (left click)
- 98
excalibur
Melee:
- 98
excalibur (died 1)
- 104
yelets
- 105
light disc
- 119
mushroom spear
- 125 Amarok
- 127 bananarang
- 129
gungnir
- 134 Hel-fire
- 134
sleepy octopod
- 134 frostbrand (beam and blade)
- 138 chain guillotines
- 142 dao of pow
- 145 drippler crippler
- 146 titanium trident (dead once)
- 150 chik
- 153 Night's edge (aggressive, staying close to head)
- 160 shadowflame knife
- 167
hallowed jousting lance
- 167
ghastly glaive, (died at last second with 56 hp on skeletron)
- 172 beam sword (beam and blade)
- 181 breaker blade
- 183 night's edge (cautious, keeping distance)
- 196 bladetongue
- 198 frostbrand (beam only)
- 201 titanium sword
- 222 sergeant united
- 231 anchor, died once
- 260 flying knife
- 284 beam sword (beam only)
- 288 Ice sickle
- phasesaber died
- obsidian swordfish died twice
- fetid baghnaks, dead
- slaphand died
- cutlass died
- dead KO-cannon, slow
- jousting lance (died twice)
- titanium chainsaw (dead
Magic:
- 85
unholy trident
- 91
tome of infinite wisdom (left click)
- 99 orange zapinator
- 115 magic dagger
- 116 shadowflame hex doll, (died at same time as boss)
- 119
rainbow rod
- 122 sky fracture
- 130 crystal serpent
- 131 cursed flames
- 137 frost staff
- 138 golden shower
- 152 flower of frost
- 153 meteor staff
- 154
magic harp
- 164 poison staff
- 165 blood thorn
- 213 medusa head
- 214 crystal vile shard
- 229 clinger staff, medium
- 229 laser rifle, safe
- 238 life drain, medium
- nimbus rod, really slow, dead
- ice rod died, ice blocked me. Probably could work, not great for this fight.
Summoner
Spider armor | Cool Whip | Firecracker | Durendal ![]() |
Abigail | 205 | 201 | 166 |
Spider | 209 | 171 | 151 |
Pirate | 225 | >270 | 167 |
Blade | 137 | 187 | 102 |
Sanguine | 115 | 95 | 100 |
Optic ![]() | 147 | 154 | 126 |
(Abigail with obsidian armor is the last thing I tried, and I was dying a lot, and she was too slow to catch up, so she's not included).
Obsidian armor | Cool Whip | Firecracker | Durendal ![]() |
Spider | 173 | 176 | 134 |
Pirate | 235 | 220 | 150 |
Blade | 134 | 196 | 109 |
Sanguine | 121 | 104 | 105 |
Optic ![]() | 134 | 156 | 123 |
Ranged:
- 67
super star shooter
- 71
megashark, ichor bullets
- 77
pulse bow, ichor arrows
- 77 daedalus stormbow, ichor arrows
- 82
megashark, crystal bullets
- 83
Phantom phoenix, ichor arrows
- 85
Flamethrower
- 89
phantom pheonix, holy arrows
- 92 uzi, ichor bullets
- 98 onyx blaster, ichor bullets
- 100
hallowed repeater, ichor arrows
- 102 Daedalus stormbow, holy arrows
- 102 onyx blaster, crystal bullets
- 112 dart pistol, ichor darts
- 114
hallowed repeater, holy arrows
- 115 dart rifle, cursed darts
- 121 Gatligator, ichor bullets
- 121 toxikarp
- 122 shadowflame bow, ichor arrows
- 123 ice bow, ichor arrows
- 126 Gatligator, crystal bullets
- 131 titanium repeater, ichor arrows
- 131 uzi, endless musket pouch
- 135 marrow, ichor arrows
- 136 shotgun, crystal bullets
- 138 shotgun, ichor bullets
- 146 titanium repeater, holy arrows
- 156 dart rifle, crystal darts
- 157 clockwork assault rifle, ichor bullets
- 184 dart pistol, crystal darts
- 218 clockwork assault rifle, crystal bullets
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