....
>-> Shoud I or...
fck it
I've yet to beat Skeletron Prime on my own *runs away crying*
...
*yells from around the corner* And I've still not gotten to post hardmode!
I would tell you how I beat him but, I think the best way to show how I dodge him is by video, for which I would have to get a video recording thing and figure out how it works, but here are some tips.
Fight him on a wooden platform arena at the very least 10 blocks in the air, because the bombs from the prime cannon don't explode on you and don't explode on platforms, so with that you will never get hit by his cannon, the best order to kill his arms in would be Laser, Saw, Vice, Cannon. But remember not to take too long in the fight or he becomes a 20000 HP Dungeon Guardian. If your trying to kill him with a mele character then you will have LOTS of trouble, I suggest using ranged or magic titanium/adamantite armor with a megashark for ranged (you can kill the destroyer, right? If not then a clockwork assault rifle) and for magic use a crystal storm/golden shower, the cursed flames aren't that great a weapon and with the platform arena they will be even worse. Or (if you can kill the twins) use a magic rod, golden shower combo, that does crazy damage!
(If you want to talk more about Skeletron Prime stratages then PM me, it could get this thread a bit off topic.)