If you are stuck with two debuffs for the whole playthrough,

[Coldshot Boostar]

Which debuffs would you choose?
I'd choose Slow

and Chilled

.

Some information, not exceptions:

These debuffs down here aren't really playable:
On Fire!

, Poisoned

, Frostburn

, Venom

, Cursed Inferno

, Burning

, Suffocation

: Going to make you die a lot before you even defeat Eye of Cthulhu.
Frozen

and Cursed

: Can't do anything.
Horrified

: Die upon spawn.
The Tongue

: You really expect Wall of flesh to spawn and drag you to hell?

Exceptions:
Stinky

, Tipsy

, Water Candle

, Midas

, Chaos State

.

Be creative. List of debuffs

 

[PTpirahna]

Chaos State and Tipsy, then go for a melee playthrough. Maybe Mana Sickness would work too.

 

[AaroSA]

Chaos state and stinky. Sure, I won't be able to use the RoD, but the odds of me getting one are low.
If that's not okay, silenced and mana sickness. I'll just use non-magic weapons.
Oops, double post. And didn't notice that stinky isn't an option. Silenced and mana sickness then.

 

[PTpirahna]

Stinky is prohibited. Literally the first thing in the post.

 

[Qw2]

Confused and Water Candle.
I would get used to Confused.
And Water Candle is more of a buff to me.

 

[ECC]

Water candle and tipsy are borderline buffs. Given the chance I'd have them.

 

[Juhou]

Water Candle and Chaos State

 

[Gotcha!]

Well, since the water candle seems to count as a debuff I'll take that one and the Mana Sickness.
Having a permanent increase in enemies is really a bonus to me though.

 

[Kyouko Tsukino]

Broken armor and mana sickness. Can't touch this.

 

[Rough Draft]

ichor and darkness, if I had to pick for the 'most negligable non-positive debuffs'. As for the most fun for a challenge, I think bleeding and potion sickness being on permanently would make for quite the difficulty spike.

 

[Enjl]

On Fire! and Cursed Inferno
Wait n- *burns to death*

I'd take Frozen and-- wait my playthrough is over? That was quick.

If I was to make a serious playthrough with permanent buffs, Bleeding and Water Candle it would be.

 

[Moartem]

Well, with inventory editing this would be indeed possible
would be really cool if yrimir did that

 

[neoselket]

silenced and bleeding. i'm a melee player.

@Coldshot Boostar, could you make it so tipsy and water candle aren't allowed? lots of people actually count those as buffs.

 

[Mihn]

Chaos State and Bleeding
Never got the RoD, and I'm good at dying so regen sholdn't be a big problem.

 

[Fortanono]

How about adding Midas to the banned list? It doesn't do anything to players.

Anyway, I'd pick something like Confused and Bleeding. Would be interesting.

 

[Bryce's Games]

2 debuffs, eh?
Screw that! I'll choose all the debuffs! *dies in .000000000001 seconds of spawning*
Well, crap.

In all seriousness, I'd have to attempt it with ichor and broken armor. Then I have -20 defense.

 

[Darkwraith332]

Hmm....Midas and Mana Sickness, then just use ranged weapons or melee.

 

[Ecna]

It is in my firm belief that having Broken Armor for the whole playthrough would be 100% impossible.

Having said that, I would most likely choose Darkness and Mana Sickness.

Lighting shouldn't be much of a problem, and considering I'm a Ranged player the only magic weapon worth using is the Nimbus Rod, which already has a low base damage so Mana Sickness won't be much of a problem.

 

[FlakMaster]

It is in my firm belief that having Broken Armor for the whole playthrough would be 100% impossible.

Playing the whole game with 0 defence is definitely possible. Defence isn't the only contributor to survival, other factors include maximum life, regeneration as well as evasive tactics to the player themelves.

 

[Murphmario]

Chaos State and Bleeding.