Defeated the Mechdusa in the zenith world I'd been dragging my feet with. It's kind of an annoying boss, because it accelerates fast enough to always catch up to you on a flat surface which means that Spazmatism will always stay in range for its flamethrower once it's close enough. You could use asphalt, but that would take a lot of foresight and luck in order to buy the crafting station from the steampunker before she dies. Aside from that, it's a very good idea to set up healing aids like heart statues to deal with the constant barrage of lasers both from Retinazer and the Destroyer's many drones. You probably won't be dodging all of them. Took four attempts.
Attempt one: Found out that it despawns instantly if you teleport too far away. I had assumed it wouldn't do that, since some other bosses don't.
Attempt two: Accidentally stepped on a teleporter and it despawned. Had the bright idea of disabling the teleporter after this.
Attempt three: Killed the Destroyer, almost killed the twins, only to run out of food (I had eaten the last pumpkin pie in my inventory and then wasted time with the previous two attemps) and then get whittled down due to general slowness and weakness.
Attempt four: It died.
I used ranged gear, which is probably the class I've used the least overall. Dart rifle with cursed flame darts, onyx blaster with crystal bullets and a golden shower for the debuff. I tried a megashark instead of the shotgun for the last attempt, but for whatever reason its damage output was pretty disappointing according to the DPS meter.