Eh, I find that I very rarely modify my hotbar. The only time I add/change things on the hotbar once I get to, say, mid-hardmode is when I update a weapon or equipment (pickaxe, etc) or if I'm doing a lot of chopping trees down and temporarily swap a weapon for acorns or something. As for getting stuff back out of chests, eh. I have my chests set up so that like materials are with each other, and the chests are within range of crafting machines. If I want to craft something, I open the appropriate chest that has the materials I need, I'm already standing next to the machine, and I can just craft the item without taking anything out of the chest 90% of the time. As for real estate, I find that 4-5 chests will accept all of the crafting materials I ever need them to, and I use another 1-2 chests for biome blocks, and 2 more chests for alchemy ingredients/potions. And I make it all *very* compact, taking up little space.