The difference is that Eye of Cthulhu has nothing else to attack you with when it chain dashes meaning you can run away in one direction while with Spazmatism you have to worry about Retinazer’s attacks.
I can attest. I tried to fight it with the Dao of Pow a while back and I get really close to dying even with (I think) Hallowed Armour.
This. On my first proper playthrough of the game I was gifted a Legendary Keybrand at the start, which carried me all the way to Plantera. The Twins were the first boss I couldn't beat within a few tries. I just kept dying to the Cursed Inferno over and over again because I had no ranged options and was too stupid to change my loadouts.
Like I said, I was gifted one by someone who'd beaten the game at the time.
*Cries in engulfed by Cursed Inferno*.
Assuming you're talking about true melee, definitely. Otherwise, Spazmatism's second phase is extremely easy because he moves extremely slowly when using his flamethrower and his dashes are pathetic.
He's a genuine threat on the 3DS version because the viewing distance on that version is small enough that he can flamethrower you from offscreen. (I assume that's why they treat him like the harder twin)
Don't kill all the limbs, because that will make the fight unnecessarily longer. Just take out the laser, and perhaps the vice, then target the skull.
That’s only normal Skeletron in Expert/Master. With Skeletron Prime, the head’s defense is always the same and it’s more realistic to just target the head always, especially because you might not have time to take out the limbs due to how tanky the boss is.
