I thought Mods were causing my game lag issue, but then I turned on Frame Skip and everything is peachy happy smooth.
Oh, also, finally started that modded run. Have Thorium, Chads Furniture, Alchemist NPC. Those are the major ones. Have a couple of Jopojelly's mods, too.
I find the idea that I'm part of some sort of builder trinity alongside @Khaios and @rulick15 to be quite inspiring and motivating!